Tetrodotoxin acts by inactivating sodium channels in nerve cells, and causes death by paralysis of the diaphragm. Tetrodotoxin binds to a different site in the channels to aconite, at it can delay its action when the two substances are administered in a particular ratio. The symptoms and death of the woman in the Japanese hotel were delayed by the presence of this pufferfish poison.
Tetrodotoxin as an antidote for aconite poisoning. Huh ....
And what did that woman in the Japanese hotel eat? A tasty Fugu-Monkshood sandwich?
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